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EFFECT OF ETHER ANAESTHESIA ON PHARMACOKINETICS OF N ‐(2 HYDROXY ETHYL) 2‐PHENYL ETHYL CARBAMATE: INHIBITION OF ITS ENTEROHEPATIC CIRCULATION
Author(s) -
OBIANWU HOPÉ O.
Publication year - 1974
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1974.tb09631.x
Subject(s) - ether , enterohepatic circulation , carbamate , ethyl carbamate , pharmacokinetics , chemistry , half life , pharmacology , plasma clearance , metabolism , biochemistry , organic chemistry , medicine , food science , wine
1 The effect of the ether anaesthesia on the plasma half‐life of N ‐(2 hydroxy ethyl) 2‐phenyl ethyl carbamate has been studied in rats. 2 The plasma half‐life of the carbamate was considerably shorter in animals anaesthetized with ether prior to drug administration than in control rats. 3 The longer plasma half‐life of the carbamate in control animals was shown to be due to enterohepatic circulation. 4 Inhibition of this phenomenon by ether was responsible for the shorter plasma half‐life of the carbamate in animals anaesthetized with this agent before drug administration. 5 The possible mechanisms by which the ether‐induced effect is brought about are discussed.