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LOWERING OF KININOGEN IN RAT BLOOD BY ADRENALINE AND ITS INHIBITION BY SYMPATHOLYTIC AGENTS, HEPARIN AND ASPIRIN
Author(s) -
CASTANIA A.,
ROTHSCHILD A.M.
Publication year - 1974
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1974.tb09612.x
Subject(s) - kininogen , chemistry , epinephrine , propranolol , in vivo , phenoxybenzamine , endocrinology , medicine , heparin , pharmacology , isoprenaline , in vitro , catecholamine , aspirin , kallikrein , biochemistry , stimulation , enzyme , biology , microbiology and biotechnology
1 (–)‐Adrenaline lowered the kininogen content and transitorily elevated the fibrinolytic activity of plasma following intravenous injection into the rat. Its effect on kininogen increased when administered by intravenous infusion. 2 Although less effective, (–)‐noradrenaline had a similar action to adrenaline; (±)‐isoprenaline was inactive and failed to inhibit the effect of adrenaline. 3 The effect of adrenaline on kininogen could be reproduced in vitro by incubation of whole blood, but not cell‐free plasma, with the catecholamine for 5 min at 37° C. 4 Propranolol or phenoxybenzamine, as well as heparin or acetylsalicylic acid (aspirin), blocked the reduction of rat blood kininogen by adrenaline in vivo and in vitro .