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MODIFICATION OF BRAIN ACETYLCHOLINE RELEASE BY MORPHINE AND ITS ANTAGONISTS IN NORMAL AND MORPHINE‐DEPENDENT RATS
Author(s) -
JHAMANDAS K.,
SUTAK M.
Publication year - 1974
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1974.tb09592.x
Subject(s) - nalorphine , morphine , acetylcholine , (+) naloxone , narcotic , pharmacology , medicine , narcotic antagonists , chemistry , anesthesia , physical dependence , endocrinology , narcotic antagonist , opioid , receptor
1 The spontaneous release of acetylcholine (ACh) from the cerebral cortex of control and morphine‐dependent rats was investigated. The rate of resting output of ACh in morphine‐dependent animals was lower than that in the control animals. 2 Administration of naloxone and nalorphine to morphine‐dependent rats was followed by a significant rise in the release of cortical ACh. In control rats no such increase in the release of ACh occurred after similar injections of narcotic antagonists. 3 Injections of morphine produced a consistent decrease in the rate of spontaneous release of cortical ACh in the control rats, but similar injections in the dependent rats did not produce a decrease in the rate of cortical ACh release. 4 The relevance of these results with regard to development of the narcotic abstinence syndrome is discussed.