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EFFECT OF CONVERTING ENZYME BLOCKADE ON ISOPRENALINE‐ AND ANGIOTENSIN I‐INDUCED DRINKING
Author(s) -
HERTTING G.,
MEYER D.K.
Publication year - 1974
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1974.tb08606.x
Subject(s) - isoprenaline , angiotensin ii , renin–angiotensin system , medicine , endocrinology , chemistry , angiotensin converting enzyme , angiotensin ii receptor type 1 , stimulation , blood pressure
1 Intravenous infusion of 0.072 μmol kg −1 h −1 (1‐Asp, 5‐Ile) angiotensin I, 0.116 μmol kg −1 h −1 of (1‐Asp β‐amid, 5‐Val) angiotensin II or of (1‐Asp, 5‐Ile) angiotensin II, caused food‐deprived and water‐satiated rats to drink about 3.0 ml of water per animal. This indicates that angiotensin I has a 1.6 times stronger dipsogenic effect than the angiotensin II preparations when infused intravenously. 2 The converting‐enzyme‐inhibitor SQ 20881 (Pyr‐Trp‐Pro‐Arg‐Pro‐Gln‐Ile‐Pro‐Pro) (1.0 mg/kg i.v.) had no intrinsic dipsogenic effect. 3 SQ 20881 given in combination with angiotensin I or angiotensin II potentiated the dipsogenic effect of angiotensin I, but not that of the two angiotensin II preparations. 4 The drinking induced by isoprenaline (100 μg/kg, i.m.) was potentiated by SQ 20881 to the same extent as drinking produced by angiotensin I infusion. 5 Angiotensin I plasma levels were determined after angiotensin I infusion and isoprenaline application. Both were significantly raised by SQ 20881. 6 It is concluded that one of the mechanisms which mediate the dipsogenic effect of isoprenaline is stimulation of the renin‐angiotensin system and that increased plasma levels of angiotensin I may play a substantial role in this type of drinking.