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HYPOTENSIVE AND VASODILATOR ACTIONS OF SK&F 24260, A NEW DIHYDROPYRIDINE DERIVATIVE
Author(s) -
FIELDEN R.,
OWEN D.A.A.,
TAYLOR E.M.
Publication year - 1974
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1974.tb08599.x
Subject(s) - papaverine , propranolol , medicine , vasodilation , vascular resistance , tachycardia , endocrinology , blood pressure , cardiology , anesthesia , chemistry
1 The blood pressure of conscious normotensive, Goldblatt‐hypertensive and genetic‐hypertensive rats and normotensive dogs was lowered by SK&F 24260 (1,4‐dihydro‐2,6‐dimethyl‐4‐(2‐trifluormethylphenyl)‐3,5‐pyridinedicarboxylic acid diethyl ester). 2 Tachycardia always accompanied the hypotension. In rats propranolol abolished the tachycardia but in dogs there was only a small reduction in the heart rate response. 3 In conscious dogs there was an increase in left ventricular output and a marked fall in total peripheral resistance. 4 SK&F 24260 dilated resistance vessels in rat hindquarters. Dilatation was caused by doses of SK&F 24260 some 50 times smaller than those of hydrallazine. 5 In preparations of cat skeletal muscle and intestinal vascular beds SK&F 24260 selectively dilated resistance vessels in preference to capacitance vessels and resembled hydrallazine rather than papaverine which has no such selectivity. 6 Pre‐capillary sphincter vessels were also dilated by SK&F 24260. Changes in fluid equilibrium caused by SK&F 24260 were consistent with selective dilatation of resistance vessels.