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INHIBITION BY NON‐STEROID ANTI‐INFLAMMATORY AGENTS OF RABBIT AORTA CONTRACTING ACTIVITY GENERATED IN BLOOD BY SLOW REACTING SUBSTANCE C
Author(s) -
FERREIRA S.H.,
VARGAFTIG B.B.
Publication year - 1974
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1974.tb08587.x
Subject(s) - arachidonic acid , aorta , chemistry , prostaglandin , pharmacology , platelet , steroid , medicine , incubation , endocrinology , biochemistry , biology , enzyme , hormone
1 A crude and a partially purified preparation of slow reacting substance C (SRS‐C) as well as arachidonic acid decreased resistance to perfusion of the dog hind paw. This effect was suppressed by treatment with non‐steroid anti‐inflammatory drugs. 2 Injections of SRS‐C or of arachidonic acid induced marked and reproducible contractions of strips of rabbit aorta and a rat stomach which were bathed in blood from an anaesthetized dog. The effect on the rabbit aorta is attributed to formation of a rabbit aorta contracting substance (RCS). The contractions were suppressed when the dog was treated with a non‐steroid anti‐inflammatory drug. 3 Incubation of blood or of platelet‐rich plasma with SRS‐C or arachidonic acid resulted in the formation of similar materials. This formation was suppressed by anti‐inflammatory drugs. 4 SRS‐C, linoleic, linolenic, and arachidonic acids are suitable substrates for soybean lipoxidase for the generation of RCS. 5 It is suggested that RCS and prostaglandin are formed within platelets, when SRS‐C or arachidonic acid are injected into animals or added in vitro . Non‐steroid anti‐inflammatory drugs suppress these effects, possibly by inhibiting prostaglandin synthetase.