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CHANGES IN MONOAMINE CONCENTRATIONS IN MOUSE BRAIN ASSOCIATED WITH ETHANOL DEPENDENCE AND WITHDRAWAL
Author(s) -
GRIFFITHS P.J.,
LITTLETON J.M.,
ORTIZ A.
Publication year - 1974
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1974.tb08582.x
Subject(s) - monoamine neurotransmitter , ethanol , withdrawal syndrome , catecholamine , physical dependence , medicine , endocrinology , kindling , chemistry , pharmacology , serotonin , stimulation , morphine , biochemistry , receptor
1 Chronic administration of ethanol to mice by inhalation induced tolerance to ethanol and produced an increase in the concentration of brain monoamines. 2 Withdrawal of ethanol from dependent mice caused behavioural changes associated with a further transient rise in brain monoamine concentrations which then declined to control levels. 3 Inhibition of the withdrawal syndrome by the administration of ethanol postponed the changes in monoamines associated with withdrawal. 4 Administration of inhibitors of catecholamine synthesis before withdrawal of ethanol modified the withdrawal syndrome.