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ABSORPTION, METABOLISM AND DISTRIBUTION OF [ 14 C]‐ O ‐METHYLDOPA AND [ 14 C]‐ l ‐DOPA AFTER ORAL ADMINISTRATION TO RATS
Author(s) -
RIVERACALIMLIM LEONOR
Publication year - 1974
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1974.tb08570.x
Subject(s) - metabolism , methyldopa , oral administration , metabolite , endocrinology , pharmacokinetics , chemistry , absorption (acoustics) , medicine , distribution (mathematics) , pharmacology , blood pressure , mathematical analysis , physics , mathematics , acoustics
1 The absorption, tissue distribution, and metabolism of [ 14 C]‐ O ‐methyldopa were compared with those of [ 14 C]‐ l ‐DOPA after oral administration to rats. 2 Total radioactivity in the plasma and brain of rats treated with [ 14 C]‐ O ‐methyldopa was significantly higher (2 fold and 30–50 fold, respectively) than that of rats treated with [ 14 C]‐ l ‐DOPA. 3 Total radioactivity in the gut washings and intestinal tissue 2 h after oral administration was significantly higher in rats treated with [ 14 C]‐ l ‐DOPA than in rats treated with [ 14 C]‐ O ‐methyldopa. The reverse was observed in the stomach tissues. 4 Peripheral metabolism of [ 14 C]‐ O ‐methyldopa was much lower than that of [ 14 C]‐ l ‐DOPA; the major metabolite of [ 14 C]‐ O ‐methyldopa in the plasma is l ‐DOPA, whereas l ‐DOPA is mainly metabolized to phenylcarboxylic acids.