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PROSTAGLANDINS, KININ AND INFLAMMATION IN THE RAT
Author(s) -
THOMAS G.,
WEST G.B.
Publication year - 1974
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1974.tb08566.x
Subject(s) - bradykinin , histamine , dextran , prostaglandin , kinin , vascular permeability , prostaglandin e , chemistry , pharmacology , prostaglandin e2 , prostaglandin d2 , inflammation , intradermal injection , prostaglandin antagonist , endocrinology , medicine , immunology , biochemistry , receptor
1 Prostaglandin E 1 and bradykinin exert synergistic effects on vascular permeability in rat skin and in rat paws. Prostaglandin E 2 is inactive in this respect. 2 Prostaglandin F 2α reduces the bradykinin response in rat skin but not in rat paws. It also markedly reduces the response of the skin to dextran, 5‐hydroxytryptamine and histamine. 3 Prostaglandin E 1 and dextran exert synergistic effects in rat skin when threshold doses of each agent are used. 4 Rats genetically resistant to dextran fail to respond to intradermal dextran in the presence of prostaglandin E 1 .