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VASCULAR REACTIVITY IN SPONTANEOUSLY HYPERTENSIVE NORMOTENSIVE AND HYPOTENSIVE RATS
Author(s) -
DUPONT J.,
SASSARD J.
Publication year - 1974
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1974.tb08560.x
Subject(s) - blood pressure , medicine , endocrinology , angiotensin ii , reactivity (psychology) , norepinephrine , renin–angiotensin system , vasoconstrictor agents , chemistry , dopamine , alternative medicine , pathology
1 Three strains of rats spontaneously hypertensive (HRS), normotensive (NS) and hypotensive (HOS), were selected by repeated inbreeding. 2 In order to explain the different blood pressure levels observed, we have studied their vascular reactivity to noradrenaline and angiotensin II. Experiments were performed in anaesthetized ganglion‐blocked, vagotomized rats. 3 The reactivity to noradrenaline was significantly higher in HRS than in NS and HOS rats. 4 The reactivity to angiotensin II appeared identical in the three strains used.