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Isoprenaline‐ and exercise‐induced tachycardia in the assessment of β‐adrenoceptor blocking drugs; a comparison between tolamolol, practolol and propranolol
Author(s) -
Adam K. R.,
Pullman L. G.,
Scholfield P. C.
Publication year - 1973
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1973.tb17268.x
Subject(s) - practolol , propranolol , isoprenaline , medicine , stimulation
The effects of tolamolol, propranolol and practolol on both isoprenaline- and exercise-induced tachycardia have been studied in conscious dogs. Tolamolol was approximately equipotent to propranolol and 50 times more potent than practolol in antagonizing exercise-induced tachycardias, but was approximately 12 times less potent than propranolol and 8 times more potent than practolol in blocking isoprenaline-induced tachycardia. It is suggested that antagonism of the tachycardia induced by exercise affords a more meaningful assessment of the possible therapeutic potential of beta-adrenoceptor blocking drugs than does that induced by isoprenaline.