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Gastric mucosal blood flow during pentagastrin‐ and histamine‐stimulated acid secretion in the rat
Author(s) -
MAIN I. H. M.,
WHITTLE B. J. R.
Publication year - 1973
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1973.tb17264.x
Subject(s) - pentagastrin , histamine , secretion , endocrinology , medicine , stimulation , gastric acid , blood flow , chemistry , biology
Summary1 Gastric mucosal blood flow was studied in the rat by means of a [ 14 C]‐aniline clearance technique. 2 There was a significant correlation between clearance and stimulated acid secretion. 3 No significant difference was found in the relationship between clearance and acid secretion during submaximal stimulation with either pentagastrin or histamine. 4 Estimates of mucosal blood flow per unit acid secretion by [ 14 C]‐aniline clearance in the rat were similar to those reported with aminopyrine clearance in the dog and cat.