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The effects of drugs on the sensitivity of the rat anococcygeus muscle to agonists
Author(s) -
GIBSON A.,
POLLOCK D.
Publication year - 1973
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1973.tb17261.x
Subject(s) - reserpine , acetylcholine , chemistry , medicine , endocrinology , inhibitory postsynaptic potential , mechanism of action , muscle contraction , pharmacology , biology , biochemistry , in vitro
Summary1 The effects of cocaine, 6‐hydroxydopamine (6‐OHDA), reserpine and 17‐β‐oestradiol on the sensitivity of the rat anococcygeus muscle to noradrenaline (NA), acetylcholine (ACh) and KCl were investigated. 2 Cocaine (10 −5 m ) increased the sensitivity of the anococcygeus to NA (100‐fold) but not to ACh or KCl. 3 6‐OHDA treatment, whether discontinuous over 6 days or continuous for 12 days, also produced a specific increase in sensitivity to NA (50‐fold). 4 Reserpine ((1 mg/kg)/day) produced a small increase in sensitivity of the muscle to NA and ACh but not to KCl, after 6 days and 12 days treatment. 5 17‐β‐Oestradiol (10 – 5 m ) had no effect on the sensitivity of the anococcygeus to NA or ACh, but reduced the sensitivity to KCl and the possible mechanism of this effect is discussed. 6 Cocaine increased, while reserpine, 6‐OHDA and 17‐β‐oestradiol decreased, the maximum response of the muscle to KCl. The response to KCl was shown to consist of at least three components; a direct action on the muscle, an effect due to release of NA, and an inhibitory action, probably due to release of the unknown inhibitory transmitter.