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The number of muscarinic receptors in chick amnion muscle
Author(s) -
CUTHBERT A. W.,
YOUNG J. M.
Publication year - 1973
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1973.tb17260.x
Subject(s) - muscarinic acetylcholine receptor , amnion , receptor , muscarinic acetylcholine receptor m2 , muscarinic acetylcholine receptor m3 , endocrinology , medicine , biology , acetylcholine receptor , acetylcholine , muscarinic acetylcholine receptor m5 , muscarinic acetylcholine receptor m1 , muscarinic acetylcholine receptor m4 , chemistry , anatomy , biochemistry , fetus , pregnancy , genetics
Summary1 [ 3 H]‐Propyl benzilylcholine mustard ([ 3 H]‐PrBCM) an irreversible specific antagonist of muscarinic acetylcholine receptors, has been used to label the muscarinic receptors in the aneuronal muscle of isolated 11 day amniotic membranes of chick embryos. 2 This muscle was found to have about 9 fmol/mg dry weight of receptor material. This is only 1–2% of the amount found in intestinal muscle. 3 Pharmacological studies with isolated amniotic membranes using PrBCM show that labelling is to functional receptors and that the receptor reserve is small. 4 The significance of the difference in receptor reserve in innervated and aneuronal plain muscle is discussed.