Effects of a morphine‐rabbit anti‐morphine antibody mixture on guinea‐pig isolated ileum | Zendy

Bleiberg M. J. | Zendy; Janicki B. W. | Zendy; Leahy W. V. C. | Zendy

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Effects of a morphine‐rabbit anti‐morphine antibody mixture on guinea‐pig isolated ileum

Author(s) -

Bleiberg M. J.,

Janicki B. W.,

Leahy W. V. C.

Publication year - 1973

Publication title -

british journal of pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.432

H-Index - 211

eISSN - 1476-5381

pISSN - 0007-1188

DOI - 10.1111/j.1476-5381.1973.tb08554.x

Subject(s) - morphine , guinea pig , ileum , sensitization , bovine serum albumin , pharmacology , chemistry , ovalbumin , medicine , gamma globulin , endocrinology , antibody , anesthesia , immunology , antigen

Incubates of morphine with serum globulins obtained from sera of rabbits immunized with a morphine-bovine serum albumin conjugate produced immediate Schultz-Dale contractions when added to superfused, electrically stimulated guinea-pig ileal strips. Incubates of morphine with Krebs-Henseleit solution produced relaxation and depression of tone, and inhibition of electrically induced contractions. It is concluded that the spasm of guinea-pig ileum produced by incubates containing morphine-binding serum globulins and morphine resulted from transient passive sensitization and an acute anaphylactic type of response.

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