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The calcium‐dependent slow after‐hyperpolarization in myenteric plexus neurones with tetrodotoxin‐resistant action potentials
Author(s) -
North R. A.
Publication year - 1973
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1973.tb08550.x
Subject(s) - myenteric plexus , tetrodotoxin , hyperpolarization (physics) , calcium in biology , chemistry , neuroscience , anatomy , calcium , medicine , biology , immunohistochemistry , stereochemistry , nuclear magnetic resonance spectroscopy
Intracellular recordings were made from neurones of the myenteric plexus of the guinea-pig ileum. The slow after-hyperpolarization which followed an action potential in some neurones was abolished by Mn(++), La(+++) and by solutions which contained no Ca(++). In these neurones, the action potential and the slow after-hyperpolarization persisted in Na(+)-free solutions or in the presence of tetrodotoxin (2 muM). The findings suggest that an inward Ca(++) current during the action potential is essential for the slow after-hyperpolarization.