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Picrotoxin antagonism of γ aminobutyric acid inhibitory responses and synaptic inhibition in the rat substantia nigra
Author(s) -
Crossman A. R.,
Walker R. J.,
Woodruff G. N.
Publication year - 1973
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1973.tb08546.x
Subject(s) - picrotoxin , substantia nigra , inhibitory postsynaptic potential , antagonism , neuroscience , pharmacology , gamma aminobutyric acid , presynaptic inhibition , chemistry , biology , dopamine , excitatory postsynaptic potential , dopaminergic , biochemistry , gabaa receptor , receptor
Neurones in the substantia nigra of the rat, anaesthetized with urethane, are inhibited both by electrical stimulation of the ipsilateral caudate nucleus and by iontophoretically applied gamma-aminobutyric acid (GABA). Iontophoretically applied picrotoxin reversibly blocks both of these inhibitory responses. These results are consistent with the hypothesis that GABA is the transmitter released by the inhibitory striato-nigral pathway.