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Blood changes in experimental arthritis in two types of genetically different rats
Author(s) -
EISEN V.,
FREEMAN PATRICIA C.,
LOVEDAY C.,
WEST G.B.
Publication year - 1973
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1973.tb08545.x
Subject(s) - polyarthritis , arthritis , adjuvant , genetically modified organism , freund's adjuvant , immunology , medicine , endocrinology , chemistry , biochemistry , gene
Summary1 Rats genetically resistant to dextran and other agents producing the anaphylactoid reaction (NR rats), have a higher polymorph count than do rats which react to these agents (R rats). 2 NR rats do not develop polyarthritis when a hind paw is injected intradermally with Freund's adjuvant. 3 The polyarthritis produced by an intravenous injection of Mycoplasma arthritidis culture develops more slowly in NR rats than in R rats. 4 It is not clear whether the higher polymorph count in NR rats is a main factor in determining their resistance to adjuvant‐induced arthritis.