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Tolerance pattern of the anorexigenic action of amphetamine in rats
Author(s) -
GHOSH M. N.,
PARVATHY S.
Publication year - 1973
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1973.tb08541.x
Subject(s) - amphetamine , food intake , period (music) , endocrinology , medicine , zoology , biology , dopamine , physics , acoustics
Summary1 When food intake in fasted male rats was recorded daily for two consecutive 2 h periods it revealed a characteristic pattern. 2 In the control rats the food intake was greater during the first than the second 2 h period. Following (±)‐amphetamine 5 mg/kg s.c. 30 min before food for 7 days there was a reversal of this normal food pattern. The rats consumed much less during the first 2 h period but progressively more during the second 2 h period. 3 The first 2 h food intake remained low throughout the treatment period and there was no evidence of development of tolerance despite continuation of treatment. 4 The second 2 h food intake steadily increased, contributing to the appearance of tolerance when only total 4 h food intake was recorded. 5 On withdrawal of amphetamine, there was immediate recovery of the first 2 h food intake. The second 2 h food intake, though decreased, remained high compared to the pretreatment level and may be responsible for the production of the ‘rebound’ phenomenon following withdrawal of amphetamine.