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Some effects of dimethyl sulphoxide (DMSO) on the frog neuromuscular junction
Author(s) -
EVANS M. H.,
JAGGARD PAMELA J.
Publication year - 1973
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1973.tb08540.x
Subject(s) - sartorius muscle , neuromuscular junction , grenouille , depolarization , cholinesterase , dimethyl sulfoxide , neuromuscular blockade , chemistry , neuromuscular transmission , rana , motor endplate , compound muscle action potential , blockade , membrane potential , electrophysiology , acetylcholine , biophysics , endocrinology , medicine , salientia , anesthesia , biochemistry , biology , neuroscience , xenopus , receptor , organic chemistry , gene
Summary1 Dimethyl sulphoxide (DMSO) partially reversed neuromuscular blockade brought about by the action of (+)‐tubocurarine or Mg 2+ on the frog sartorius nerve‐muscle preparation. 2 The amplitude and duration of the endplate potential (e.p.p.) were increased by DMSO at concentrations of 70 m m or greater. 3 Miniature endplate potentials were raised in frequency, prolonged in duration and increased in amplitude by DMSO at concentrations of 141 m m or greater, but the increase in amplitude was generally less than in the case of the e.p.p. 4 The resting muscle membrane potential was significantly depolarized by DMSO at 70 m m or greater concentrations, both at the endplate and remote from an endplate. 5 The reversal of neurmuscular blockade by DMSO can be explained in terms of its previously reported ability to inhibit cholinesterase activity, together with the depolarizing action on muscle.