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Cellular localization of the uptake of 5‐hydroxytryptamine in the area postrema of the rabbit after injection into a lateral ventricle
Author(s) -
DOW R. C.,
LASZLO I.,
RITCHIE ISOBEL M.
Publication year - 1973
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1973.tb08533.x
Subject(s) - area postrema , pargyline , ependyma , chemistry , endocrinology , medicine , third ventricle , cerebral ventricle , serotonin , anatomy , biology , central nervous system , receptor
Summary1 The cellular localization of 5‐hydroxytryptamine (5‐HT) was investigated in the area postrema of the rabbit after intraventricular injection under different experimental conditions. 2 5‐HT was found to be acccumulated in different parts in and near to the area postrema, e.g. in glial cells, dorsal surface of the area postrema and ependyma of the central canal. 3 The concentrations of 5‐HT and 5‐hydroxy indol‐3‐yl acetic acid (5‐HIAA) were measured in different parts of the brain and CSF in control and in 5‐HT treated animals with and without pargyline pretreatment. Intraventricular injection of 5‐HT increased the concentration of 5‐HT and 5‐HIAA in the brain and in the CSF; pretreatment with pargyline further increased the concentrations of 5‐HT but decreased the concentration of 5‐HIAA.