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Brain levels of Δ 1 ‐tetrahydrocannabinol and its metabolites in mice tolerant to the hypothermic effect of Δ 1 ‐tetrahydrocannabinol
Author(s) -
Lawrence D. K.,
Pertwee R. G.
Publication year - 1973
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1973.tb08388.x
Subject(s) - tetrahydrocannabinol , δ9 tetrahydrocannabinol , chemistry , delta 9 tetrahydrocannabinol , pharmacology , cannabinoid , biochemistry , biology , receptor
Repeated voluntary consumption of cannabis in milk (approximately 8 mg per day for 15 days) produced in mice tolerance to the hypothermic effect of tritiated Delta(1)-tetrahydrocannabinol ([(3)H]-Delta(1)-THC; 2 mg/kg i.v.) but not to the effect of [(3)H]-Delta(1)-THC on immobility index. The development of tolerance was not accompanied by any detectable change in levels of radioactivity in the brain assigned to Delta(1)-THC or its metabolites. It was concluded that changes in metabolism or distribution of Delta(1)-THC are not responsible for tolerance at least to the hypothermic effect of Delta(1)-THC in mice.