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Some effects of burimamide on the isolated perfused pulmonary circulation of the guinea‐pig
Author(s) -
Goadby P.,
Phillips Elizabeth A.
Publication year - 1973
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1973.tb08386.x
Subject(s) - mepyramine , histamine , guinea pig , metiamide , stimulation , medicine , chemistry , pharmacology , endocrinology , receptor , antagonist , histamine h2 receptor
Infusions of burimamide were found to potentiate the pressor response to histamine and abolish the depressor response to histamine in the presence of mepyramine, in the isolated perfused guinea-pig pulmonary circulation. It is concluded that the depressor response to histamine is due to stimulation of histamine H(2)-receptors in the pulmonary vessels.