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Histamine H 2 ‐receptors modulate systemic anaphylaxis: a dual cardiovascular action of histamine in calves
Author(s) -
Eyre P.,
Wells P. W.
Publication year - 1973
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1973.tb08385.x
Subject(s) - mepyramine , histamine , anaphylaxis , histamine receptor , antagonist , medicine , pharmacology , endocrinology , histamine h4 receptor , vasoconstriction , histamine h1 receptor , vasodilation , chemistry , histamine h2 receptor , receptor , immunology , allergy
Depressor changes in carotid blood pressure caused by histamine or anaphylaxis in calves, were incompletely blocked by the H(1)-receptor antagonist mepyramine. Burimamide, the selective histamine H(2)-receptor antagonist, potentiated the depressor actions of histamine and anaphylaxis. Potentiated depressor responses were inhibited by mepyramine. Observations are consistent with histamine stimulating both H(1)- and H(2)-receptors to cause respectively vasodilatation and vasoconstriction.