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Possible modulating influence of frontal cortex on nigro‐striatal function
Author(s) -
GLICK S. D.,
GREENSTEIN S.
Publication year - 1973
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1973.tb08378.x
Subject(s) - amphetamine , denervation , frontal cortex , cortex (anatomy) , lesion , dextroamphetamine , dopaminergic , medicine , neuroscience , anesthesia , anatomy , dopamine , psychology , surgery
Summary1 After administration of (+)‐amphetamine, rats with unilateral ablations of the frontal cortex rotated either ipsilaterally or contralaterally as a function of time after surgery. 2 At early postoperative intervals (1–7 days), rotation was towards the side of the lesion. 3 At later times (15–30 days), rotation was towards the intact side. 4 Repeated testing with amphetamine appeared to slow the time‐course of changes in rotational behaviour. 5 These results suggest that a dopaminergic nigro‐striatal system is modulated by the frontal cortex and that unilateral removal of the latter produces a denervation supersensitivity of the former.