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Effects of chlorpromazine on exploration and habituation in the rat
Author(s) -
FILE SANDRA E.
Publication year - 1973
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1973.tb08376.x
Subject(s) - habituation , chlorpromazine , motor activity , psychology , placebo , anesthesia , neuroscience , medicine , developmental psychology , audiology , pharmacology , alternative medicine , pathology
Summary1 The effects of chlorpromazine, 2 and 4 mg/kg, on exploration were investigated under two independent influences—food deprivation and time of day. 2 Rats had three 3‐minute trials in a hole‐board apparatus; hole‐investigation (head‐dips) and general motor activity were recorded. 3 On trial 1 chlorpromazine reduced exploration to half the control level, but on trial 3 it had no effect on motor activity or head‐dips. 4 General activity habituated from trial 1 to 3 in all groups, but some of the drug groups did not show significant habituation of head‐dips, due to the low level of responding on trial 1.