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Release of rabbit aorta contracting substance (RCS) and prostaglandins induced by chemical or mechanical stimulation of guinea‐pig lungs
Author(s) -
PALMER M. A.,
PIPER PRISCILLA J.,
VANE J. R.
Publication year - 1973
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1973.tb08368.x
Subject(s) - guinea pig , stimulation , rabbit (cipher) , aorta , chemistry , thoracic aorta , substance p , anatomy , medicine , pharmacology , endocrinology , biochemistry , receptor , neuropeptide , statistics , mathematics
Summary1 Rabbit aorta contracting substance (RCS) and prostaglandins were released from guinea‐pig isolated perfused lungs by gentle massage and also by infusion of Prosparol. 2 RCS and prostaglandins were also released by infusion into the pulmonary artery of bradykinin, arachidonic and dihomo‐γ‐linolenic acids or shock perfusate (containing RCS‐releasing factor). 3 Arachidonic and dihomo‐γ‐linolenic acids caused a prolonged release of RCS and prostaglandins whereas bradykinin and shock perfusate gave a short‐lasting output. 4 RCS and prostaglandins, together with histamine were released when super‐fused chopped lung tissue was agitated. 5 Challenge of sensitized guinea‐pigs in vivo led to the release of an RCS‐like substance into the carotid arterial blood. 6 Intravenous injection of bradykinin into guinea‐pigs also released an RCS‐like substance. 7 The release of RCS and prostaglandins was inhibited by aspirin or indomethacin in all experiments. 8 RCS contracted all vascular tissues investigated and also rat stomach strip. 9 The half‐life of RCS was estimated as 1–2 minutes.