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Fate of angiotensin I in the toad Bufo melanostictus
Author(s) -
NG K. K. F.
Publication year - 1973
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1973.tb08353.x
Subject(s) - angiotensin ii , medicine , renin–angiotensin system , endocrinology , toad , kidney , angiotensin iii , blood pressure , chemistry , angiotensin converting enzyme , biology , angiotensin receptor
Summary1 The effects of angiotensin I and II on the blood pressure of pithed toads and the disappearance of angiotensin I and II in the perfused organs of the toad were studied. 2 Angiotensin I was relatively inactive on the blood pressure of pithed toads; it exhibited less than 3% of the pressor activity of angiotensin II. 3 Angiotensin I was not converted to angiotensin II during passage through the lungs. There was also no evidence of net conversion during passage through the kidney and hind quarters. 4 During passage through the lungs, 33–50% of angiotensin I was removed and 25–50% was removed during passage through the hind quarters. No loss of activity was detected when angiotensin II passed through the kidneys. 5 Angiotensin II passed through the lungs and kidneys without loss but 25–50% disappeared during passage through the hind quarters. 6 The relatively low pressor activity of angiotensin I together with its lack of conversion to angiotensin II in isolated perfused organs suggest that the converting enzyme is absent in the toad, Bufo melanostictus.