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Response of the rat ileum, uterus and vas deferens to carbachol and acetylcholine following repeated daily administration of a cholinesterase inhibitor
Author(s) -
FOLEY D. J.,
McPHILLIPS J. J.
Publication year - 1973
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1973.tb08350.x
Subject(s) - carbachol , vas deferens , ileum , uterus , acetylcholine , endocrinology , medicine , cholinesterase , cholinergic , chemistry , receptor
Summary1 Daily i.p. administration, for eight days, of the cholinesterase inhibitor disulfoton to rats produced mild to moderate signs of intoxication (tremors, incontinence and diarrhoea) but no deaths. 2 Segments of ileum taken from the treated rats were subsensitive to carbachol but the vas deferens and the uterus did not exhibit any change in sensitivity to carbachol. 3 The sensitivity to acetylcholine was increased in the ileum and vas deferens but not in the uterus. 4 Acetylcholinesterase activity was 60–70% inhibited in all three tissues.