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Effects of quazodine (MJ 1988) on contractions of the isolated hemidiaphragm of the rat and the biventer cervicis muscle of the chick
Author(s) -
NOTT M. W.,
WINSLOW EILEEN
Publication year - 1973
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1973.tb08349.x
Subject(s) - carbachol , theophylline , acetylcholine , chemistry , neostigmine , calcium , muscle contraction , contractility , caffeine , pharmacology , endocrinology , medicine , biochemistry , biology , receptor , organic chemistry
Summary1 The effects of quazodine and theophylline have been studied on the rat hemidiaphragm and chick biventer cervicis preparations in vitro.2 Theophylline and quazodine enhanced maximal twitches and contractural responses to acetylcholine and carbachol. 3 These actions on contractility were exerted directly upon the muscle fibres and were dependent upon the concentration of calcium ions in the bathing solution. 4 In addition, quazodine enhanced the neuromuscular blocking activity of tubocurarine, probably by a prejunctional action. 5 Theophylline potentiated acetylcholine to a greater extent than it potentiated carbachol thus suggesting that theophylline possesses anticholinesterase activity.