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The dependence of paracetamol absorption on the rate of gastric emptying
Author(s) -
HEADING R. C.,
NIMMO J.,
PRESCOTT L. F.,
TOTHILL P.
Publication year - 1973
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1973.tb08339.x
Subject(s) - gastric emptying , medicine , absorption (acoustics) , gastroenterology , stomach , materials science , composite material
Summary1 The rate of gastric emptying was measured directly in 14 convalescent hospital patients and paracetamol absorption was studied following an oral dose of 1·5 g. 2 Rapid gastric emptying was associated with the early appearance of high peak plasma paracetamol concentrations whereas peak concentrations were low and occurred late when gastric emptying was slow. 3 There was a significant correlation between the rate of gastric emptying and the 0·4 and 0·24 h urinary excretion of paracetamol and its metabolites. 4 In five patients with abnormally slow gastric emptying the mean maximum plasma concentration and 0·4 and 0·24 h urinary excretion of paracetamol were significantly lower than in seven patients with normal gastric emptying rates while the time taken to reach maximum plasma concentrations was longer. 5 Individual differences in the rate of gastric emptying may contribute to variable absorption of many drugs.