Premium
Inhibition by γ‐hydroxybutyrate of chlorpromazine‐induced increase in homovanillic acid
Author(s) -
ROTH R H.
Publication year - 1973
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1973.tb08338.x
Subject(s) - chloral hydrate , homovanillic acid , chlorpromazine , haloperidol , stupor , anesthesia , chemistry , glutethimide , pharmacology , medicine , endocrinology , dopamine , biochemistry , receptor , serotonin , vomiting
Summary1 γ‐Hydroxybutyrate and its lactone precursor, γ‐butyrolactone, when administered in anaesthetic doses block the increase in the cerebral concentration of homovanillic acid normally observed after administration of chlorpromazine or haloperidol. 2 Other hypnotics such as glutethimide, urethane, chloralose, chloral hydrate and thiopentone do not have this ability even when administered in anaesthetic doses. 3 The ability of γ‐hydroxybutyrate to block the neuroleptic‐induced increase in cerebral homovanillic acid is not due to a reduction in body temperature since a similar effect is observed in rats treated under conditions (32° C) in which body temperature remains normal. 4 Possible mechanisms for this action of γ‐hydroxybutyrate are discussed.