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Selective blockade of β‐adrenoceptors by 1‐( p ‐allylphenoxy)‐3‐isopropylamino‐2 propanol hydrochloride (H 64/52) in the anaesthetized dog
Author(s) -
LEVY B.
Publication year - 1973
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1973.tb08337.x
Subject(s) - isoprenaline , blockade , vasodilation , medicine , heart rate , hydrochloride , endocrinology , stimulation , blood pressure , perfusion , chemistry , anesthesia , receptor , organic chemistry
Summary1 The β‐adrenoceptor blocking properties of l‐( p ‐allylphenoxy)‐3‐isopropylamino‐2‐propanol hydrochloride (H 64/52) on the cardiovascular and broncho‐motor responses to isoprenaline have been determined in the anaesthetized dog. 2 H 64/52 selectively blocked the isoprenaline‐induced increase in heart rate, contractile force and reduction in airway pressure in the same dose range. 3 H 64/52 produced a minimal blockade of vascular β‐adrenoceptors which was apparent only when the isoprenaline‐induced fall in diastolic pressure was considered. No significant vascular β‐adrenoceptor blockade with H 64/52 could be shown with the femoral arterial flow or hind‐limb perfusion studies. 4 These results further support the hypothesis that several different β‐adrenoceptor subtypes exist in the dog. The β‐adrenoceptors subserving cardiac stimulation and bronchodilation appear to be similar and both differ from the β‐adrenoceptor subserving vasodilatation.