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Effects of salicylates on blood changes in mycoplasma arthritis in rats
Author(s) -
EISEN V.,
LOVEDAY C.
Publication year - 1973
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1973.tb08325.x
Subject(s) - polyarthritis , erythrocyte sedimentation rate , immunology , lysozyme , mycoplasma , arthritis , sodium salicylate , rheumatoid arthritis , antibody , immune system , immunity , microbiology and biotechnology , biology , medicine , chemistry , biochemistry
Summary1 The polyarthritis produced in rats by i.v. inoculation with Mycoplasma arthritidis was made more severe by salicylates. 2 The infection increased the erythrocyte sedimentation rate (ESR), serum lysozyme, counts of total white blood corpuscles, polymorphonuclear cells and lymphocytes, haemolytic serum complement (CH 50) and its component C3. Salicylates enhanced the rise in ESR, CH 50 and C3, but suppressed the rise in lymphocytes and even induced a fall. 3 Salicylates did not interfere with the development and action of metabolic inhibition antibodies against M. arthritidis , and did not promote the growth of M. arthritidis.4 Rats treated with salicylate during the first infection acquired the same immunity to reinfection as did infected controls. 5 Salicylates did not render rats susceptible to M. fermentans which is nonpathogenic to rats, but may be involved in human rheumatoid arthritis.