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Interaction of bretylium and guanethidine on the relaxations of the rat isolated fundal strip preparation, evoked by indirect stimulation
Author(s) -
GAITONDÉ B. B.,
NIMBKAR A. Y.
Publication year - 1973
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1973.tb08324.x
Subject(s) - guanethidine , bretylium , stimulation , medicine , pharmacology , chemistry , anesthesia , endocrinology , neuroscience , psychology , adrenergic , receptor
Summary1 Isolated rat stomach fundal strip bathed in Krebs solution containing atropine (1 μg/ml), responded to indirect stimulation by a relaxation which was frequency dependent. These responses were blocked by phenoxybenzamine (6 ftg/ml) or phentolamine (8 μg/ml). 2 Strips obtained from rats previously treated with reserpine did not show relaxation to indirect stimulation. These responses were therefore adrenergic in nature. 3 Bretylium (0·1–100 μg/ml) failed to block the relaxations produced by indirect stimulation, in fact relaxations were potentiated by the drug. 4 Guanethidine (10 μg/ml) blocked the relaxations induced by indirect stimulation. 5 Guanethidine may be taken up by adrenergic nerves actively since its action is not seen at 12° C. 6 Bretylium (10 μg/ml) prevented the actions of guanethidine at 37° C.