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Central noradrenergic neurones and the cardiovascular actions of clonidine in the rabbit
Author(s) -
DOLLERY C. T.,
REID J. L.
Publication year - 1973
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1973.tb08318.x
Subject(s) - clonidine , blood pressure , medicine , heart rate , monoaminergic , anesthesia , mean arterial pressure , serotonin , receptor
Summary1 Clonidine (1 μg/kg), given by intracisternal injection to anaesthetized rabbits, lowered mean arterial blood pressure by 33 mmHg and heart rate by 32 beats/min. 2 In animals pre‐treated with 6‐hydroxydopamine (6‐OHD 500 μg/kg intracisternally) 7–10 days before, intracisternal clonidine (1 μg/kg) reduced mean arterial blood pressure by only 2·5 mmHg and heart rate by 4 beats/minute. 3 The hypotensive action of intravenous clonidine was reduced to 49% of control by pre‐treatment with intracisternal 6‐OHD. In unanaesthetized normal animals intravenous clonidine (30 μg/kg) lowered mean arterial blood pressure by 19·3 mmHg, while after 6‐OHD it fell only 94 mmHg. 4 These studies suggest that the central hypotensive effect of clonidine is dependent on the integrity of central monoaminergic neurones.