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Adrenoceptors and adenyl cyclase in gills
Author(s) -
Cuthbert A. W.,
Pic P.
Publication year - 1973
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1973.tb08277.x
Subject(s) - citation , library science , fish <actinopterygii> , biology , computer science , fishery
The content of cyclic 3',5'-adenosine monophosphate (cAMP) in the gills of the mullet (Mugil capito) has been measured. The basal level was found to be 2.9+/-0.3 pmol/mg wet weight. When fish were first anaesthetized with MS222 (tricaine) and the gills perfused to remove blood, the concentration of cAMP was raised to 14.3+/-1.9 pmol/mg wet weight.Adrenaline caused a significant increase in cAMP content, an effect that was blocked by propranalol, a beta-adrenoceptor antagonist. In the presence of the alpha-adrenoceptor block- ing agent phentolamine, adrenaline still caused an increase in nucleotide content.The results are discussed in relation to adrenaline and the adenyl cyclase system.