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The effects of hallucinogenic drugs on maze exploration in the rat over a 24 hour period
Author(s) -
DAVIES J. A.,
REDFERN P. H.
Publication year - 1973
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1973.tb08274.x
Subject(s) - mescaline , amphetamine , period (music) , hallucinogen , dextroamphetamine , physiology , medicine , pharmacology , dopamine , physics , acoustics
Summary1 The variation with clock‐hour in the behaviour of naive rats in a Y‐maze has been recorded. 2 The number of entries recorded was highest during the light period while the number of faecal boluses was highest during the dark period. Rearing showed a biphasic periodicity. 3 The responses to LSD, mescaline and amphetamine also showed significant variation with clock‐hour. 4 In general, amphetamine, 1·25 mg/kg, increased the number of entries and the number of rears, the effect being greatest at the end of the light period. LSD, 100 μg/kg, and mescaline, 12·5 mg/kg, decreased the number of entries and the number of rears. 5 All three drugs decreased the number of faecal boluses. The possible significance of these responses in terms of an effect on the emotional state of the animals is discussed.