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Assessment of selective β‐adrenoceptor blockade in man
Author(s) -
BRIANT R. H.,
DOLLERY C. T.,
FENYVESI T.,
GEORGE C. F.
Publication year - 1973
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1973.tb08272.x
Subject(s) - practolol , chronotropic , isoprenaline , inotrope , blockade , medicine , antagonism , vasodilation , endocrinology , blood pressure , heart rate , propranolol , receptor , stimulation
Summary1 Selective antagonism of the cardiac β 1 ‐adrenoceptors has been studied in normal human volunteers. 2 Practolol and UK 6558 produced greater antagonism of the chronotropic and inotropic responses to i.v. isoprenaline than of the vasodilator response to either i.v. or intra‐arterial isoprenaline. A third drug, M&B 17,803A, produced non‐selective β‐adrenoceptor blockade in 2 of 3 subjects studied. 3 Practolol, UK 6558 and M&B 17,803A, produced an attenuation of the responses to Valsalva's manoeuvre. 4 A substantial reduction in blood pressure was seen in 3 of 4 normotensive subjects given UK 6558.