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Prostaglandins and the mechanism of analgesia produced by aspirin‐like drugs
Author(s) -
FERREIRA S. H.,
MONCADA S.,
VANE J. R.
Publication year - 1973
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1973.tb08270.x
Subject(s) - bradykinin , aspirin , reflex , prostaglandin , medicine , blood pressure , analgesic , anesthesia , pharmacology , free nerve ending , chemistry , endocrinology , receptor
Summary1 Resting splenic venous outflow from anaesthetized dogs contains prostaglandin‐like material: the concentration increases after intra‐arterial injections of bradykinin into the spleen, and is abolished by treatment with indomethacin. 2 Intra‐arterial injections of bradykinin into the spleen of lightly anaesthetized dogs elicit a dose‐dependent reflex increase in the blood pressure, which is reduced but not abolished by treatment with indomethacin. 3 Addition of prostaglandin E 1 or E 2 either by injections or by infusions restores the reflex increase in the blood pressure due to bradykinin injections after indomethacin treatment. 4 The sensitizing action of endogenously released prostaglandins at or near the afferent nerve endings is discussed. 5 The analgesic activity of aspirin‐like drugs is explained in terms of the removal of the sensitizing activity of prostaglandins.