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Anti‐inflammatory and some other pharmacological effects of 3,4‐ trans ‐2,2‐dimethyl‐3‐phenyl‐4‐[ p ‐(β‐pyrrolidinoethoxy)‐phenyl]‐7‐methoxy‐chroman (Centchroman)
Author(s) -
DHAWAN B. N.,
SRIMAL R. C.
Publication year - 1973
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1973.tb08268.x
Subject(s) - stereochemistry , chemistry , pharmacology , medicine
Summary1 Anti‐inflammatory, analgesic, antipyretic and other pharmacological activities of a new chroman derivative, Centchroman, have been described. 2 Centchroman was found to possess significant anti‐inflammatory action in the carrageenin‐induced oedema test in mice and rats. It inhibited granuloma formation in the cotton pellet test. The anti‐arthritic activity was also evident in formaldehyde‐induced arthritis and adjuvant‐induced arthritis in rats. 3 Centchroman had a lower ulcerogenic index than phenylbutazone. 4 The mechanism of the anti‐inflammatory action of Centchroman seemed to be independent of endogenous adrenocortical hormones or of its weak oestrogenic activity. 5 Centchroman antagonized phenylquinone writhing and bradykinin‐induced bronchospasm but was devoid of any antipyretic activity.