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Effects of cocaine or denervation on responses of isolated strips of cat spleen to (‐)‐noradrenaline and (‐)‐isoprenaline
Author(s) -
GRANATA A. R.,
LANGER S. Z.
Publication year - 1973
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1973.tb08255.x
Subject(s) - isoprenaline , reserpine , endocrinology , medicine , denervation , spleen , norepinephrine , methoxamine , chemistry , sympathectomy , stimulation , dopamine , agonist , receptor
Summary1 A study has been made of the effects of cocaine and sympathetic denervation on responses of the cat spleen to (–)‐noradrenaline and (–)‐isoprenaline. 2 Responses of isolated strips of spleen capsule to (–)‐noradrenaline or to (–)‐isoprenaline were not affected by reserpine‐pretreatment. 3 In adult cats, cocaine (1 and 10 μg/ml) or denervation produced a shift to the left of dose‐response curves to (–)‐noradrenaline, whereas they failed to modify dose‐response curves to (–)‐isoprenaline. 4 There was an increase in the maximum development of tension to (–)‐noradrenaline after denervation or in the presence of cocaine (10 μg/ml). These procedures did not increase the maximal responses to (–)‐isoprenaline. 5 Cocaine (10 μg/ml) did not affect dose‐response curves to (–)‐noradrenaline or (–)‐isoprenaline in the denervated spleen. 6 In the kitten spleen, cocaine (1 and 10 μg/ml) produced a shift to the left of dose‐response curves to (–)‐noradrenaline both in untreated and in reserpine‐pretreated tissues. 7 There was a small shift to the left in dose‐response curves to (–)‐isoprenaline in the presence of cocaine in the untreated but not in the reserpine‐pretreated kitten spleen. 8 It is concluded that the potentiation of responses to (–)‐noradrenaline in the cat's spleen is due to a prejunctional effect of cocaine.