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Anaphylaxis in the guinea‐pig isolated heart: selective inhibition by burimamide of the positive inotropic and chronotropic effects of released histamine
Author(s) -
CAPURRO NORINE,
LEVI R.
Publication year - 1973
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1973.tb08249.x
Subject(s) - chronotropic , inotrope , histamine , guinea pig , pharmacology , anaphylaxis , medicine , chemistry , endocrinology , heart rate , immunology , allergy , blood pressure
Summary1 Anaphylaxis was induced in the isolated heart of the guinea‐pig in the presence of burimamide at concentrations of 4 × 10 −5 M and 2·7 × 10 −4 M. 2 Burimamide did not affect the immunological release of histamine; however, it selectively antagonized the positive inotropic and chronotropic effects of released histamine. The antagonism of the positive chronotropic effect was concentration‐dependent. 3 Neither the negative dromotropic effect nor the decrease in coronary flow rate occurring during anaphylaxis were inhibited by burimamide. 4 The results are in agreement with the double histamine receptor theory and suggest that, in the heart of the guinea‐pig, H 2 ‐receptors are involved in the positive inotropic and chronotropic effects of released histamine, and H 1 ‐receptors in the negative dromotropic effect.