Premium
Interaction between tyramine and iproniazid on guinea‐pig atria
Author(s) -
JALÓN P. D. GARCIA,
MARTINEZSIERRA R.,
VELASCO A.
Publication year - 1973
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1973.tb08247.x
Subject(s) - iproniazid , tyramine , reserpine , monoamine oxidase , guinea pig , pharmacology , tranylcypromine , monoamine oxidase inhibitor , chemistry , medicine , endocrinology , biology , biochemistry , enzyme
Summary The inhibition of monoamine oxidase (MAO) by iproniazid may be antagonized by large doses of tyramine as shown by the restoration, or otherwise, of inotropic responses to tyramine in isolated atria from guinea‐pigs that had been treated with reserpine.