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The effects of an anti‐atherosclerotic drug, pyridinolcarbamate, on heart, vascular and brain biogenic amines
Author(s) -
Berkowitz B. A.,
Hidaka H.,
Spector S.
Publication year - 1973
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1973.tb08239.x
Subject(s) - medicine , drug , cardiology , pharmacology
The anti-atherosclerotic drug pyridinolcarbamate was investigated in the rat for its effects on heart, blood vessel and brain biogenic amines. The drug increased the concentration of noradrenaline in all tissues and of noradrenaline and 5-hydroxytryptamine in the brain. The possibility of a link between biogenic amines and atherosclerotic disease is discussed.