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Monoamine oxidase and aldehyde dehydrogenase activity in the striatum of rats after 6‐hydroxydopamine lesion of the nigrostriatal pathway
Author(s) -
Agid Y.,
Javoy F.,
Youdim M. B. H.
Publication year - 1973
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1973.tb08238.x
Subject(s) - monoamine oxidase , hydroxydopamine , striatum , dopamine , nigrostriatal pathway , monoamine neurotransmitter , chemistry , endocrinology , lesion , medicine , aldehyde dehydrogenase , neuroscience , biochemistry , substantia nigra , enzyme , psychology , dopaminergic , serotonin , pathology , receptor
Monoamine oxidase and aldehyde dehydrogenase activity were significantly reduced in the striatum of rats 8 days after lesion of the nigrostriatal nerve pathway caused by 6-hydroxydopamine. Evidence is presented for the existence of an intraneuronal 'dopamine monoamine oxidase' and intraneuronal aldehyde dehydrogenase. Dopamine concentrations were reduced to 10% of their control values.