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Microiontophoretic release of drugs from micropipettes: use of 24 Na as a model
Author(s) -
CLARKE G.,
HILL R. G.,
SIMMONDS M. A.
Publication year - 1973
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1973.tb08234.x
Subject(s) - iontophoresis , pipette , biophysics , chemistry , pharmacology , anesthesia , medicine , neuroscience , biology
Summary1 The use of 24 Na + of high specific activity allowed its iontophoretic release from multibarrelled glass micropipettes to be followed over short periods with low currents. 2 When a negative retaining current was passed to reduce diffusional efflux between the periods of positive current expulsion of 24 Na + , the rate of release of 24 Na + during the expulsion period progressively increased during the first minute before becoming constant. 3 The currents employed were similar to those normally used to regulate the microiontophoretic release of potent drugs such as γ‐aminobutyric acid. It is therefore concluded that, during the usual period of response to such drugs, the rate of release of drug is not constant but increasing. 4 The implications of these observations for the construction of microiontophoretic dose‐response relationships is discussed.