Premium
Some observations on the β‐adrenoceptor agonist properties of the isomers of salbutamol
Author(s) -
BRITTAIN R. T.,
FARMER J. B.,
MARSHALL R. J.
Publication year - 1973
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1973.tb08232.x
Subject(s) - salbutamol , agonist , pharmacology , chemistry , adrenergic receptor , selectivity , receptor , medicine , endocrinology , asthma , biochemistry , catalysis
Summary1 The pharmacological activities of the optical isomers of salbutamol have been examined. (–)‐Salbutamol was much more potent than (+)‐salbutamol on β‐adrenoceptors. 2 Both (–)‐ and (+)‐salbutamol showed high selectivity for β‐adrenoceptors in bronchial muscle compared to cardiac muscle, in this way resembling racemic salbutamol. 3 The use of isomeric activity ratio to detect differences between receptors was examined in the light of the results obtained with the isomers of salbutamol.