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Effect of cocaine on the affinity of α‐adrenoceptors for noradrenaline
Author(s) -
INNES I. R.,
MAILHOT R.
Publication year - 1973
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1973.tb08231.x
Subject(s) - phenoxybenzamine , norepinephrine , chemistry , pharmacology , medicine , endocrinology , adrenergic receptor , receptor , dopamine
Summary1 Doses of cocaine which cause specific or unspecific supersensitivity in cat spleen did not alter the blocking effect of phenoxybenzamine on the responses of isolated cat spleen strips to noradrenaline. 2 The same doses of cocaine did not increase the protection of α‐adrenoceptors given by noradrenaline during a standard exposure to phenoxybenzamine. 3 It is concluded that cocaine does not change the affinity of the α‐adrenoceptor for noradrenaline, and therefore changes in affinity are not responsible for the potentiating action of cocaine.