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Characterization of α‐adrenoceptors in the myocardium
Author(s) -
BENFEY B. G.
Publication year - 1973
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1973.tb08230.x
Subject(s) - phenoxybenzamine , phentolamine , phenylephrine , inotrope , refractory period , adrenergic receptor , medicine , endocrinology , chemistry , blockade , propranolol , pharmacology , receptor , blood pressure
Summary1 In the driven rabbit left atrium α‐adrenoceptors mediate the inotropic effect of phenylephrine and the prolongation of functional refractory period by sympathomimetic amines. 2 These receptors are highly sensitive to blockade by phentolamine and phenoxybenzamine. 3 Prolongation of functional refractory period is greater with the secondary amines, phenylephrine, adrenaline and epinine, than with the primary amines, norphenylephrine, noradrenaline and dopamine.